Thirtyeight children received iron sucrose for nonrenal indications, with iron deficiency refractory to oral iron therapy, with iron malabsorption or dependence on parenteral nutrition, 7 for chronic gastrointestinal blood loss, and 5 for miscellaneous indications. Efficacy and safety of intravenous iron sucrose in treating. Iron is critical for normal hemoglobin synthesis to maintain oxygen transport. Each ml contains 20 mg elemental iron as iron sucrose in water for injection. Iron sucrose may also be used for purposes not listed in this medication guide. What are the possible side effects of iron sucrose venofer. Hb may 21, 2015 in one aspect, the application provides a process for preparation of iron sucrose complex having molecular weight of 34,000 to 60,000 daltons comprising. Although not all of these side effects may occur, if they do occur they may need medical attention. Indications iron deficiency anemia patients with chronic kidney disease pregnant woman with iron deficiency patients who cannot tolerate oral therapy 6. Find information on iron sucrose venofer in daviss drug guide including dosage, side effects, interactions, nursing implications. A test dose is not required, but has been used at the physicians discretion in 1 of 3 clinical u. Additionally, iron is necessary for metabolism and synthesis of dna and various enzymatic processes.
It is normally administered in 100 mg doses, times each week and it is not recommended to use doses above 300 mg. Call your doctor right away if you have chest pain, cough or the need to cough, dizziness, passing out, shortness of breath, sweating, or throat tightness. Iron sucrose venofer daviss drug guide nursing central. Torres s, kuo yh, morris k, neibart r, holtz jb, davis jm. What is the most important information i should know about iron sucrose venofer. Venofer iron sucrose injection, usp, an iron replacement product, is a brown, sterile, aqueous, complex of polynuclear iron iiihydroxide in sucrose for intravenous use. Venofer iron sucrose injection, usp is an established and effective treatment for chronic kidney disease ckd patients experiencing iron deficiency anemia. Recommended to store in a wellclosed container, protected from direct sunlight and moisture. For the treatment of iron deficiency anemia in patients with chronic kidney disease. Capitals indicate life threatening, underlines indicate most frequent. Oct 31, 2019 you will be watched closely by your doctor for 30 minutes after each dose. Iron sucrose is not for treating other forms of anemia not caused by iron deficiency.
Check with your doctor or nurse immediately if any of the following side effects occur. Iron sucrose injection has a molecular weight of approximately 34,000 to 60,000 daltons and a proposed structural formula. Jan 01, 2019 pediatric patients 2 years of age and older with hddckd for iron maintenance treatment. Along with its needed effects, a medicine may cause some unwanted effects. It may also be used in conjunction with pharmacological agents for relief of pain associated. Patients are calculated based on an estimated annual cumulative dose. Iron polysaccharide an overview sciencedirect topics. The harriet lane handbook app and website provides pediatric diagnosis and treatment, pediatric management algorithms, and pediatric drug formulary from experts at johns. Sucrose administration guideline june 2012 m jonsson, crn sucrose 24% oral solution use in pediatrics note a physicians order is needed for the use of sucrose purpose. Common and rare side effects for iron sucrose intravenous. Feb 06, 2020 iron sucrose is used to treat iron deficiency anemia in people with kidney disease. To provide short term pain relief for infants and children up to the age of 6 months.
Intravenous iron therapy venofer or feraheme or iron. Find information about common, infrequent and rare side effects of iron sucrose intravenous. The drug contains approximately 30% sucrose wv 300 mgml. In another clinical study, 1 patients received a 50 mg 2. Iron sucrose intravenous route side effects mayo clinic. Look up information on diseases, tests, and procedures. To view the entire topic, please sign in or purchase a subscription. Pediatric patients 2 years of age and older with hddckd for iron maintenance treatment. Capitals indicate lifethreatening, underlines indicate most frequent. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. Iron sucrose is used to treat iron deficiency anemia in people with kidney disease iron sucrose is for use in adults and children at least 2 years old. Iron sucrose is not for treating other forms of anemia not caused by iron deficiency iron sucrose may also be used for purposes not listed in this medication guide. Recommended to store in a wellclosed container, protected from direct sunlight and moisture retest period. Venofer is available in 5 ml single dose vials 100.
Bioavailability and stability of intravenous iron sucrose. There are no data on the effects of iron sucrose on. Venofer iron sucrose injection, usp rx only description venofer iron sucrose injection, usp is a brown, sterile, aqueous, complex of polynuclear iron iiihydroxide in sucrose for intravenous use. Venofer is indicated for the treatment of iron deficiency anemia in patients.
Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron sucrose intravenous route description and brand. Ferrlecit sodium ferric gluconate complex in sucrose injection is a stable macromolecular complex used to replete and maintain the total body content of iron. Efficacy and safety of intravenous iron sucrose in. Iron sucrose is present in human milk, and available data after exposure to 100 to 300 mg of intravenous iron sucrose have not reported adverse reactions in breastfed infants. It is administered intravenously and is only used when a patient with iron deficiency cannot be treated using oral iron options. Nov 09, 2018 iron sucrose is a form of the mineral iron. Iv dosage is expressed in terms of milligrams of elemental iron. Bloating or swelling of the face, arms, hands, lower legs, or feet. Sucrose is a disaccharide formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose. Find patient medical information for iron sucrose intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Iron sucrose is for use in adults and children at least 2 years old.
Oct 18, 2014 each ml contains 20 mg elemental iron as iron sucrose in water for injection. Ferrlecit was given to both dose groups in eight divided doses during sequential dialysis sessions a period of 16 to 17 days. In one aspect, the application provides a process for preparation of iron sucrose complex having molecular weight of 34,000 to 60,000 daltons comprising. Iron is a mineral that the body needs to produce red blood cells.
Intravenous iron sucrose for children with iron deficiency. Physicians have trusted venofera to treat 20 million patientsaand counting. A complex of polynuclear iron iii hydroxide in sucrose. Sucrose 24% oral solution use in pediatrics saskpain.
When the body does not get enough iron, it cannot produce the number of normal red blood cells needed. What should i discuss with my healthcare provider before i receive iron sucrose venofer. Venofer is used to treat iron deficiency anemia in people with kidney disease. Intravenous iron sucrose has been used for decades for the treatment of anemia. Used iv for the treatment of iron deficiency anemia in patients with chronic kidney disease and orally for control of. New generic iron sucrose products are now marketed for the use in several countries and there is an ongoing discussion about the safety and efficacy of iron sucrose. Iron sucrose injection has a molecular weight of approximately 34,000 60,000 daltons and a proposed structural formula. Intravenous iron therapy venofer or feraheme or iron dextran. Myths and misconceptions denise margaret harrisona,b,c, a school of nursing, the university of melbourne, melbourne, australia b department of neonatology, royal childrens hospital, melbourne, australia. Limited data indicate iron found in breast milk is not increased after intravenous administration of iron sucrose. Test procedures adopted from the monograph of iron sucrose injection usp. It has a role as an osmolyte, a sweetening agent, a human metabolite, an algal metabolite, a saccharomyces cerevisiae metabolite, an escherichia coli metabolite and a mouse metabolite. Hemodialysis patients on erythropoietin therapy showed significant increases in serum iron and serum ferritin after 4 weeks of treatment with venofer. To evaluate the efficacy and safety of intravenous iron sucrose is in the treatment of adults with iron.
Ferrlecit sodium ferric gluconate complex in sucrose. It is dissociated by the reticuloendothelial system res into iron and sucrose. Iron sucrose is a parenteral iron formulation used for the treatment of iron deficiency anemia due to hemodialysis or other conditions. Venofer iron sucrose dose, indications, adverse effects. Iron sucrose injection is an iron replacement product that is used to treat iron deficiency anemia not enough iron in the blood in patients with chronic kidney disease ckd. Each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0. Learn about side effects, interactions and indications. Fat emulsion intralipid, liposyn iii daviss drug guide. Myths and misconceptions denise margaret harrisona,b,c, a school of nursing, the university of melbourne, melbourne, australia b department of neonatology, royal childrens hospital, melbourne, australia c department of paediatrics, the university of melbourne, melbourne, australia d critical care and neurosciences theme, murdoch childrens. Venofer iron sucrose dosing, indications, interactions. Severe iron deficiency requires intravenous iron supplementation to replenish iron stores.
Protocol for the use of intravenous iron sucrose venofer. You will be watched closely by your doctor for 30 minutes after each dose. Ferrlecit sodium ferric gluconate complex in sucrose injection. Oral iron should not be taken while iv iron is being administered it should be recommenced five days after the completion of iv iron sucrose the patient must have first dose of iv iron sucrose given by a doctor if they not received this drug within beaumont hospital before. Ferrlecit 25 mg of elemental iron and were then randomly assigned to receive ferrlecit at cumulative doses of either 500 mg low dose or mg high dose of elemental iron. Iron sucrose intravenous route description and brand names.
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